PLEKHG2-associated neurological disorder

Apotemnophilia: a neurological disorder.

Apotemnophilia, a disorder that blurs the distinction between neurology and psychiatry, is characterized by the intense and longstanding desire for amputation of a specific limb. Here we present evidence from two individuals suggestive that this condition, long thought to be entirely psychological in origin, actually has a neurological basis. We found heightened skin conductance response to pin...

Obsessional Disorder and Neurological Illness.

Obsessions and compulsions are mental experiences with a compelling quality which persistently intrude into consciousness. Although recognized by the patient as an abnormal and irrational product of his own mind, and resisted by him, he is incapable of expelling them. They may take the form of thoughts, images, fears, urges, desires, or acts. An obsessional illness is one where such symptoms do...

Small vessel vasculitis presenting as neurological disorder.

Three patients with skin or muscle biopsy evidence of small vessel vasculitis presented with neurological symptoms: (1) frequent transient ischaemic attacks, (2) myalgia with encephalopathy, and (3) myalgia with marked weakness. The diagnosis of small vessel vasculitis needs consideration especially if presentation with polyneuropathy or cutaneous involvement is associated with elevation of ESR...

Substance Dependence as a Neurological Disorder

Paraneoplastic Neurological Disorder in Nasopharyngeal Carcinoma.

Paraneoplastic neurological disorder (PND) is a condition due to immune cross-reactivity between the tumour cells and the normal tissue, whereby the "onconeural" antibodies attack the normal host nervous system. It can present within weeks to months before or after the diagnosis of malignancies. Nasopharyngeal carcinoma is associated with paraneoplastic syndrome, for example, dermatomyositis, a...